Moffitt / Mayo Clinic Physical Sciences in Oncology Center

"Our research investigates the evolutionary dynamics that drive cancers and uses our understanding of evolution against the cancer"



"Evolutionary and ecological dynamics of tumor-host interactions"


"Clinical translation of evolutionary and ecological principles"


"Bench-to-Bedside Core"




"Training and Outreach within the Moffitt PSOC"




PSOC Leadership

Robert A. Gatenby, M.D.

Chair of Radiology


Robert J. Gillies, Ph.D.

Chair of Cancer Imaging and Metabolism

Alexander R. A. Anderson, Ph.D.

Chair of the IMO




Latest PSOC News



2018 Summer internship opportunity 

Cheating dynamics in prostate cancer

Project mentors: Dr. Robert Gatenby, Dr. Joel Brown

Undergraduate students interested in solving complex problems in cancer through interdisciplinary research are encouraged to apply by February 16, 2018. Please click here to request an application package.

  • Open to Rising Junior and Senior Undergraduates
  • Applicant must be a United States citizen or permanent resident attending college in the U.S.
  • $4000 Stipend + Free Housing
  • Support for Travel to/from Research Institution
  • Two-Day Research Conference at the NIH in Bethesda, MD
  • 16 opportunities for Projects available at 14 different research institutions.

Sponsored by the National Cancer Institute of the NIH

Download the Moffitt PSOC project description here.

Seminar Series

Olivier Elemento, PhD

Director, Englander Institute for Precision Medicine; Associate Director, Institute for Computational Biomedicine; Co-Leader, Genetics, Epigenetics and Systems Biology Program, Meyer Cancer Center, New York, NY

"A cancer precision medicine program driven by multi-omics, analytics and modeling"

March 30th, 2018



Applications are now being accepted for the High school Internship Program in Integrated Mathematical Oncology.

Go to the HIP IMO website
for application forms and detailed information. 




HIP IMO Spotlight: 

Two HIP IMO students, Samantha Lee and Saharsh Agrawal, coauthor on Encyclopedia chapter with Drs. Rejniak and Karolak

"Single-Cell-Based In Silico Models: A Tool for Dissecting Tumor Heterogeneity"

-Reference Module in Biomedical Sciences (2018)

ISBN: 978-0-12-801238-3


Recent Publications


Emmons, M. F., et al. (2017). MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma. Sci Rep 7(1): 2685.

Zhao, X., et al. (2017). Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma. Nat Commun 8: 14920.

Gatenby RA, Brown J. (2017). Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer. Biochim Biophys Acta. 2017 Apr. doi: 10.1016/j.bbcan.2017.03.005

Ibrahim-Hashim A, Robertson-Tessi M, Enriquez-Navas PM, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson ARA, Gillies RJ, Gatenby RA. (2017) Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res. 2017 May 1. doi: 10.1158/0008-5472.CAN-16-2844

Brown J, Cunningham JJ, Gatenby RA. (2016). Aggregation Effects and Population-based dynamics as a source of therapy resistance in cancer. IEEE Trans Biomed Eng. 2016 Nov 1. doi:10.1109/TBME.2016.2623564

Nichol D, Robertson-Tessi M, Jeavons P, Anderson AR. (2016) Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging. Genetics 2016 Dec.

Damaghi M, Gillies RJ. (2016) Lysosomal protein relocation as an adaptation mechanismto extracellular acidosis. Cell Cycle2016 Jul 2. doi: 10.1080/15384101.2016.1176394.

Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA. (2016) Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces. Cancer Res. 2016 Jun 1. doi: 10.1158/0008-5472.CAN-15-2962

Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. (2016) Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer. Sci Transl Med. 2016 Feb 24. doi:10.1126/scitranslmed.aad7842.

Pilon-Thomas, S., Kodumedi KN, El-Kenawi AE, Russell S, Weber AM, Luddy K, Damaghi M, Wojtkowiak JW, Mule JJ, Ibrahim-Hashim A, Gillies RJ. (2016) Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy. Cancer Res. Mar 15 2016. doi: 10.1158/0008-5472.CAN-15-1743


HIP IMO 2017:


The Moffitt HIP IMO 2017 has concluded! Follow @MoffittPSOC for updates on future internships.