Moffitt / Mayo Clinic Physical Sciences in Oncology Center

"Our research investigates the evolutionary dynamics that drive cancers and uses our understanding of evolution against the cancer"

  


 


"Evolutionary and ecological dynamics of tumor-host interactions"


 


"Clinical translation of evolutionary and ecological principles"


 


"Bench-to-Bedside Core"


 

 

 


"Training and Outreach within the Moffitt PSOC"


 

 




 

PSOC Leadership

Robert A. Gatenby, M.D.

Chair of Radiology

 

Robert J. Gillies, Ph.D.

Chair of Cancer Imaging and Metabolism

Alexander R. A. Anderson, Ph.D.

Chair of the IMO

 


 

 

Latest PSOC News

Headlines:

 

Upcoming Workshop:

October 29th - November 3rd, 2017

IMO Workshop 7: Stroma

Moffitt Cancer Center, Stabile Research Building, Tampa FL

The IMO Department is hosting their 7th workshop from October 29 - November 3. The workshop is designed to motivate and facilitate hands-on modeling experience focused on metastasis. The workshop is comprised of both an educational event and competition.

 

 

PSOC Spotlight: May 17th, 2017 Moffitt MRI Signals: Miles for Moffitt/Heiko Enderling, PhD

 

 

Educator Award: Congratulations to Dr. Heiko Enderling, Co-Lead for Moffitt PSOC's Education and Outreach core and chair of the PSON education working group, for being named 2016 Moffitt Research Educator of the Year.

 

 

FLiiCR Internship: Congratulations to our very own FLiiCR student Enakshi Sunassee on winning a student research award for her poster “Characterization of migration phenotype of pancreatic cancer cell lines” at last weekend’s Annual Biomedical Research Conference for Minority Students (ABRCMS), held at the Tampa Convention Center past week/weekend.

Recent Publications

 

Emmons, M. F., et al. (2017). MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma. Sci Rep 7(1): 2685.

Zhao, X., et al. (2017). Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma. Nat Commun 8: 14920.

Gatenby RA, Brown J. (2017). Mutations, evolution and the central role of a self-defined fitness function in the initiation and progression of cancer. Biochim Biophys Acta. 2017 Apr. doi: 10.1016/j.bbcan.2017.03.005

Ibrahim-Hashim A, Robertson-Tessi M, Enriquez-Navas PM, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson ARA, Gillies RJ, Gatenby RA. (2017) Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res. 2017 May 1. doi: 10.1158/0008-5472.CAN-16-2844

Brown J, Cunningham JJ, Gatenby RA. (2016). Aggregation Effects and Population-based dynamics as a source of therapy resistance in cancer. IEEE Trans Biomed Eng. 2016 Nov 1. doi:10.1109/TBME.2016.2623564

Nichol D, Robertson-Tessi M, Jeavons P, Anderson AR. (2016) Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging. Genetics 2016 Dec.

Damaghi M, Gillies RJ. (2016) Lysosomal protein relocation as an adaptation mechanismto extracellular acidosis. Cell Cycle2016 Jul 2. doi: 10.1080/15384101.2016.1176394.

Lloyd MC, Cunningham JJ, Bui MM, Gillies RJ, Brown JS, Gatenby RA. (2016) Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces. Cancer Res. 2016 Jun 1. doi: 10.1158/0008-5472.CAN-15-2962

Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. (2016) Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer. Sci Transl Med. 2016 Feb 24. doi:10.1126/scitranslmed.aad7842.

Pilon-Thomas, S., Kodumedi KN, El-Kenawi AE, Russell S, Weber AM, Luddy K, Damaghi M, Wojtkowiak JW, Mule JJ, Ibrahim-Hashim A, Gillies RJ. (2016) Neutralization of Tumor Acidity Improves Antitumor Responses to Immunotherapy. Cancer Res. Mar 15 2016. doi: 10.1158/0008-5472.CAN-15-1743


 

HIP IMO 2017:

 

The Moffitt HIP IMO 2017 has concluded! Follow @MoffittPSOC for updates on future internships.